It’s a form of hemolytic anemia where the M protein destroys red blood cells. Doctors may also recommend a stem cell transplant in certain situations. Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. However, these therapies are usually effective at treating the disease. Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. Some patients with Waldenstrom's may have smoldering disease that's sort of like a precancer where they have detectable disease in the bone marrow, they have an elevated IgM but no symptoms. This can result in low levels of red blood cells, normal white blood cells, and platelets. There’s no cure for WM, but many different treatments are available to help manage symptoms… READ MORE Instead, routine blood tests for a physical exam or other reason reveal abnormal results. About 25% of people have no symptoms when doctors diagnose the disease. 7,752,060 and 8,719,052. One way doctors classify NHL is by the type of lymphocyte involved—either T-cells or B-cells. Because of this, another name for WM is lymphoplasmacytic lymphoma. Our discussions are not a substitute for seeking medical advice or care from your own doctor. Count on us for updates on the coronavirus and guidance for cancer patients and family members. One of the main recommended treatments would be a chemotherapy called bendamustine (Treanda), and then after a cycle or two, once we get those IgM levels down, we'll combine that with the rituximab antibody therapy. If they have more urgent symptoms and need urgent treatment, then we will often combine that with something else. Inherited genetic mutations from your parents can make you more vulnerable to certain cancers. The Third International Workshop on Waldenstrom’s Macroglobulinemia established the following definitions of response to treatment: Educational Forum Doctors discover some cases when they are examining people for other reasons. Anemia: this condition is characterized by a low red blood cell count leading to fatigue and other symptoms. So, for asymptomatic WM, watchful waiting is often an option. All Rights Reserved. That's called hyperviscosity and that would require urgent treatment. Waldenstrom macroglobulinemia (WM) is an uncommon form of non-Hodgkin lymphoma (NHL). About 25% of people have no symptoms when doctors diagnose the disease. Third Party materials included herein protected under copyright law. That’s how you’ll get care that’s most appropriate for you. WM is also referred to ... protein may lead to many symptoms, including fatigue, unexplained weight loss, enlarged lymph nodes or … Regarding Waldenstrom macroglobulinema treatment, Dr. Larry Anderson shares, “It’s really a personalized decision between the patient and the doctor,” as he explains that treating. Publications, LIFELINE and One-on-One Support WM is a cancer of a type of white blood cell called lymphoplasmacytic cells (LPL cells). Vincent is a CLL patient and shares his experiences with chronic lymphocytic leukemia treatment. Clotting or bleeding problems: these are due to abnormal levels of clotting factors or platelets. The survey will appear at the end of your visit. In general, M protein levels alone aren’t a useful guide for treatment. Vision problems: this occurs as a result of M protein deposition leading to poor circulation or bleeding from tiny blood vessels. The period after treatment when a WM patient has experienced either stabilization of disease, an improvement in laboratory values and in physical signs and symptoms, or perhaps disease progression is called a “response.”  While an improvement is sometimes commonly referred to as a “remission," the preferred scientific terminology is “response.”. Waldenstrom macroglobulinemia occurs when lymphocytes grow uncontrollably. Hyperviscosity syndrome requires urgent treatment. International Waldenstrom's Macroglobulinemia Foundation 6144 Clark Center Ave. Sarasota, FL 34238 Phone 941-927-4963 Fax 941-927-4467 EIN: 54-1784426 WM cells can also crowd out normal cells in the bone marrow. When symptoms occur, they are usually vague and nonspecific, and can include: As M protein builds up in the body and blood, it can cause other problems and symptoms including: Amyloidosis: this occurs when M protein affects organs, such as the kidneys or heart, causing damage.