The Grignard Reaction – Synthesis of Triphenylmethanol Andrea Mxxxxxxx 216 Section 176 Experiment 10 MM/DD/2010 With a dry 1 mL syringe, slowly add the solution to the reaction vessel containing the Grignard reagent, thus maintaining a gentle reflux. Grignard Reaction 9 Chem 355 Jasperse Grignard Synthesis of Triphenylmethanol I. BackgroundIn 1912 Victor Grignard received the Nobel prize in chemistry for his work on the reaction that bears his name, a carbon-carbon bond-forming reaction by which almost any alcohol may be formed from appropriate alkyl halides and carbonyl compounds. The Grignard reagent is easily formed by reaction of an alkyl halide, in particular a bromide, with magnesium metal in anhydrous diethyl ether. To assess the purity of the product by determining its melting point. This synthesis begins with the formation of the Grignard reagent from bromobenzene in ether in the presence of crushed magnesium turnings. In an oven dried vial, dissolve benzophenone (364 mg, 2 mmol) in 1 mL of anhydrous ether. They are often used to form alcohols by reaction with aldehydes and ketones. To react the Grignard reagent with a ketone and an ester. Grignard reagents are created by reacting magnesium with either an alkenyl or alkyl halide. Once the Grignard reagent, phenyl magnesium bromide, is formed, the benzophenone is added. Synthesis of Triphenylmethanol Objectives To use the Grignard reagent in a water free environment. In 1912, Victor Grignard received the Nobel prize in chemistry for his discovery of a new series of reactions that … Although the reaction can be written and thought of in a simple format (1) it appears that the structure of the material in solution is rather more complex. The use of Grignard reagents to produce compounds such as triphenylmethanol has been found to be not only a useful method of synthesizing an extended variety of functional groups but also to be a versatile technique. In the Lab To purify the product via recrystallization. To perform a cost-analysis of the two reactions. Experiment 12: Grignard Synthesis of Triphenylmethanol Reactions that form carbon-carbon bonds are among the most useful to the synthetic organic chemist. Grignard reagents are strong bases that will react with acidic hydrogens, and they are excellent nucleophiles. The presence of water in the process of generating Grignard reagent will causes the particular reagent to be decomposed. All equipment and solutions must be kept completely free of water. In order to synthesis triphenylmethanol, Grignard reagent is playing an important role because Grignard reagent is the key reagent in this experiment. Rinse the benzophenone vial with a small amount of anhydrous ether and add this to the reaction tube also. Formation of triphenylmethanol. The halide group must be bromide, iodide, or chloride.